Schedule

Our conference is split over 3 days – May 26th until May 28th – starting with an opening lecture from Herbert Waldmann.

The ECBS2021 further includes 9 sessions (S1 – S9) and two dedicated evening sessions on special topics:
“Covid-19 research” and “Gender & diversity” (Ev1 and Ev2).

Based on their profile and submitted abstract Jakob Kljun and Michał Jakubczyk have been nominated by the organizing committee of ECBS2021 and EuChemS representatives for the first Young Investigator Workshop of the EuChemS Division of Chemistry in Life Sciences (please find more information here: https://yiw2021.eu/).

ALL TIMES ARE CET. CENTRAL EUROPEAN TIME (Berlin).

MAY
26

Wednesday

10:00	Welcome Francesco Peri, Wolfgang Fecke
10:15	Opening Lecture Herbert Waldmann (Max-Planck Insitute of Molecular Physiology) Pseudo Natural Products – Chemical Evolution of Natural Product Structure
S 1	Nanomedicine and biomaterials Chair: Claudia Bonfio
11:15	Marco Di Antonio (Imperial College London) Single-molecule visualisation of DNA G-quadruplex formation in live cells.
11:45	Oral communication: Alberto Dal Corso (University of Milan) New-generation Self-Immolative Spacers for Fast and Controlled Release of Anticancer Drugs
12:00	Oral communication: Riccardo Marin (Autonomous University of Madrid) Infrared-emitting multimodal nanostructures for controlled in vivo magnetic hyperthermia
12:15	Oral communication: Giuseppe Arrabito (University of Palermo) Printing Biology: where printing meets synthetic biology
12:30	Flash presentation: Chiara Pizzolitto (University of Trieste) Dual cross-link hydrogels with tunable viscoelasticity control stem cell differentiation
12:35	Flash presentation: Francesca Cardano (University of Milan) Squaraine NIR dyes: a structure to function study for novel bilayer membrane probes
12.45	Lunch Break (75 minutes)
S 2	Targeted protein degradation Chair: Wolfgang Fecke
14:00	Alessio Ciulli (University of Dundee) How PROTAC degraders work and why the ternary complex matters
14:30	Georg Winter (Research Center for Molecular Medicine of the Austrian Academy of Sciences) Identification and Characterization of novel molecular glue degraders
14:50	Oral communication: Andrea Astolfi (University of Perugia) A novel class of small molecule degraders targeting prion protein folding intermediate
15:10	Oral Communication: Felix Hausch (University Darmstadt) De novo identification of a fully synthetic FKBP12-FRB Molecular Glue
15:25	Coffee Break (15 minutes)
S 3	Artificial intelligence & computational drug design Chair: Giuliana D’Ippolito, Sonsoles Martin-Santamaria
15:40	Andreas Bender (University of Cambridge) Using Artificial Intelligence and Chemical and Biological Data for Drug Discovery: Opportunities and Pitfalls
16:10	Rebecca Wade (Heidelberg Institute for Theoretical Studies) Combining molecular simulation and machine learning approaches for structure-based drug design
16:30	Oral communication: Albert Antolin (The Institute of Cancer Research, London) From probe to drug: Polypharmacology across drug discovery
16:45	Oral Communication: Katarzyna Walczewska-Szewc (Nicolaus Copernicus University) The changes in prolyl oligopeptidase structure upon inhibition modify its ability to decrease alpha-synuclein aggregation
17:00	Flash presentation: Alejandra Matamoros-Recio (Center for Biological Research (CIB) Margarita Salas / CSIC) Computational approaches to the dynamics and activation mechanism of Toll-like receptor 4
17:05	Conclusions

Ev 1	EVENING SESSION: Gender & Diversity Chair: Sonsoles Martin-Santamaria, Katja Herzog
17:45	Angela Agostiano (Past President of Società Chimica Italiana – Italian Chemical Society) Empowering diversity in science
18:05	Questions & Answers
18:30	Movie screening: “Picture a scientist” https://www.pictureascientist.com/ Sign up in advance for the screening here (60 tickets only, first come first served!): https://pas-eu-openscreen-berlin.eventbrite.de
20:00 (approx.)	Interactive discussion
20:45	Conclusions

MAY
27

Thursday

10:00	Welcome Francesco Peri, Wolfgang Fecke
S 4	Platforms in drug discovery Chair: Paola B. Arimondo, Gianluca Sbardella
10:05	Angelo Fontana (University of Naples “Federico II”) Natural Small Molecules in Chemical Immunology
10:35	Christian Hackenberger (Leibniz Research Institute for Molecular Pharmacology) The power of chemoselectivity: Functional protein-conjugates for intra- and extracellular targeting
10:55	Stefan Laufer (Tübingen University) Covalent Inhibitors re–invented
11:15	Maria Duca (Côte d’Azur University – CNRS) Design and implementation of small-molecule RNA binders for anticancer and antimicrobial therapies
11:35	Annika Jenmalm-Jensen (SciLifeLab) Academic Drug Discovery capabilities at SciLifeLab, Sweden.
11:55	Päivi Tammela (University of Helsinki) EU-OPENSCREEN Academic Compound Library – Sourcing compounds from the chemistry community for new discoveries
12:10	Oral communication: Lukas Roth (University of Sydney) Immobilized Metal Affinity Chromatography as a Potential Drug Discovery Platform
12:25	Oral communication: Sebastian Pomplun (Massachusetts Institute of Technology) Combinatorial discovery of synthetic biohybrid ligands for RNA-hairpins and for the SARS-CoV-2-spike protein
12:40	Flash presentation: Elva Morretta (University of Salerno) Label-free functional proteomics links the anti-angiogenic properties of the pyrazolyl-urea GeGe-3 to Calreticulin binding
12:45	Flash presentation: Evgeny Kulesskiy (University of Helsinki) Development of small molecule inhibitors of the endocytic cytoskeleton
12:50	Flash presentation: Callum Rosser (University of Sydney) The synthesis and activity of analogues of the HDAC inhibitor panobinostat with added hydrogen bonding capacity
12:55	Flash presentation: Cosmin Butnarasu (University of Turin) Understanding the mechanisms governing the interaction of drugs with mucus using a novel biosimilar mucus model
13:00	Lunch Break (30 minutes)
S 5	Fighting resistant pathogens; new antiviral therapies Chair: Cristina Airoldi, Francesco Peri
13:30	Mark Brönstrup (Helmholtz Centre for Infectious Research) Assault, Siege or Trojan Horse Strategy: Use of Natural Products to Fight Bacterial Infections
14:00	Vito Ferro (University of Queensland) Synthetic Heparan Sulfate Mimetics Potently Inhibit SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction
14:20	Sara Sattin (University of Milano) Interfering with bacterial survival strategies
14:35	Boris Vauzeilles (Paris-Sud University) Detecting pathogens and Reactive Oxygen Species using Chemical Biology
14:50	Oral communication: Anna Hirsch (Helmholtz Institute for Pharmaceutical Research Saarland) Discovery of antibacterial agents inhibiting the energy-coupling factor (ECF) transporters by structure-based virtual screening
15.05	Break (5min)
S 6	Natural compound chemistry and biology Chair: Valeria Costantino, Giuliana D’Ippolito
15:10	Laura Steindler (University of Haifa) Defining host-microbe interactions in a basal metazoan: the sponge.
15:40	Jeanette H. Andersen (University of Tromsoe) Arctic marine biodiversity as a source for novel compounds
16:00	Pedro Leao (University of Porto) Incorporation and modification of fatty acids in cyanobacterial secondary metabolism.
16:20	Oral communication: Slava Ziegler (Max Planck Institute of Molecular Physiology) Morphological Profiling of Small Molecules for Mode-of-Action Prediction
16:35	Oral Communication: Francisco Castillo (MEDINA Foundation) Target-based screening strategies for the identification of novel natural products as protein-protein interaction inhibitors
16:50	Oral Communication: Deniz Tasdemir (GEOMAR Centre for Marine Biotechnology) Metabolomics-Assisted Discovery of Bioactive Marine Natural Products
17:05	Flash presentation: Angela Casillo (University of Naples Federico II) Bacterial mannan polysaccharide: chemical structure and conformational studies
17:10	Conclusions

Ev 2	EVENING SESSION: Covid19 research Chair: Gabriele Costantino (EFMC representative)
19:00	Welcome by Rui Moreira (EFMC, iMED Lisboa)
19:10	Philip Gribbon (Fraunhofer ITMP Screening Port Hamburg) Compound repurposing by target based and phenotypic approaches to identify in-vitro inhibitors of SARS-CoV2 viral entry and replication
19:30	Oral communication: Kamyar Hadian (Helmholtz Zentrum München, Molecular toxicology and pharmacology) Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 and other betacoronaviruses
19:45	Flash presentation: Miguel Santos (NOVA University Lisbon) *potentially pre-recorded Enhanced formulations of Hydroxychloroquine as Organic Salts and Ionic Liquids to fight COVID-19
19:50	Flash presentation: Wieslaw Nowak (Nicolaus Copernicus University) Nanomechanics of nanobodies-protein S SARS-CoV-2 virus complexes revealed by a Virtual Atomic Force Microscope
19:55	Panel discussion: Covid19 – challenges and next steps
20:30	Conclusions

MAY
28

Friday

10:00	Welcome Francesco Peri, Wolfgang Fecke
S 7	Protein aggregation and self-assembly in disease Chair: Cristina Airoldi, Michael Assfalg
10:05	Giuseppe Melacini (McMaster University) Atomic Resolution Map of the Soluble Amyloid Beta Assembly Toxic Surfaces
10:35	Salvador Ventura (Autonomous University of Barcelona – UAB) Finding new drugs for conformational diseases
10:55	Daniel Otzen (Aarhus University) Enlisting microfluidics to screen for inhibitors of toxic protein aggregates in Parkinson’s Disease and other disruptors of protein-protein interactions
11:15	Oral communication: Francesca Munari (University of Verona) Impact of ubiquitination on the aggregation of Tau protein, a key player in Alzheimer’s disease
11:30	Flash presentation: Serena Vittorio (University of Messina) In silico modeling of small molecules as α-synuclein aggregation inhibitors
11.35	Lunch Break (55 minutes)
S 8	Glycochemistry & -biology Chair: Anna Bernardi
12:30	Christoph Rademacher (University of Vienna) Carbohydrate receptor ligands enable targeted delivery to immune cells
13:00	Jeroen Codee (Leiden University) Of sugars and phosphates: synthesis and application of well-defined bacterial oligosaccharide structures
13:30	Carme Rovira (University of Barcelona) Using computers to understand how carbohydrates are processed in nature
13:50	Oral Communication: Gavin Miller (Keele University) Chemoenzymatic synthesis of sugar nucleotide chemical biology tools to explore the GDP-D-mannose dehydrogenase from Pseudomonas aeruginosa
14:05	Flash Presentation: Maria Isabel Garcia-Moreno (University of Seville) GalNAc-related sp2-iminosugars as mutant lysosomal β-hexosaminidase A activity enhancers in late-onset Tay-Sachs disease patients’ fibroblasts
14:10	Coffee Break (20 minutes)
S 9	Origin of Life & synthetic biology Chair: Claudia Bonfio
14:30	Matthew Powner (University College London) On the unified chemical origins of peptides and nucleic acids
15:00	Dora Tang (Max Planck Institute of Molecular Cell Biology and Genetics) Coacervates as protocellular models?
15:20	Kamila Muchowska (University of Strasbourg) Non-enzymatic metabolic reactions and life’s origins
15:40	Oral Communication: Roger Rubio-Sánchez (University of Cambridge) A Modular, Dynamic, DNA-based Platform for Regulating Cargo Distribution and Transport between Lipid Domains
15:55	Flash presentation: Karina Nakashima (Radboud University) Active coacervate droplets: protocells that grow and survive
Pr	Prize ceremony Chair: Katja Herzog, Sonsoles Martin-Santamaria, Francesco Peri
16:00	Best oral, flash or poster presentation (selected from submitted abstracts) in the field of 1) Organic chemistry interfacing Biology* 2) Innovative hit compounds and biomaterials for drug discovery and development* 3) Innovative approaches in life science* 4) Chemical tools in biology 5) Chemical glycobiology 6) Natural products in chemical biology** sponsored by the Society of Chemistry of Italy (SCI). Divisions of Organic Chemistry, Medicinal Chemistry and Chemistry in Life Sciences. *sponsored by the Spanish Royal Society of Chemistry (RSEQ). Divisions of Chemical Biology, Carbohydrates and Natural Products.
16:15	Conclusions

MAY 26

Wednesday

Nanomedicine and biomaterials

Chair: Claudia Bonfio

Targeted protein degradation

Chair: Wolfgang Fecke

Artificial intelligence & computational drug design

Chair: Giuliana D’Ippolito, Sonsoles Martin-Santamaria

EVENING SESSION: Gender & Diversity

Chair: Sonsoles Martin-Santamaria, Katja Herzog

MAY 27

Thursday

Platforms in drug discovery

Chair: Paola B. Arimondo, Gianluca Sbardella

Fighting resistant pathogens; new antiviral therapies

Chair: Cristina Airoldi, Francesco Peri

Natural compound chemistry and biology

Chair: Valeria Costantino, Giuliana D’Ippolito

EVENING SESSION: Covid19 research

Chair: Gabriele Costantino (EFMC representative)

MAY 28

Friday

Protein aggregation and self-assembly in disease

Chair: Cristina Airoldi, Michael Assfalg

Glycochemistry & -biology

Chair: Anna Bernardi

Origin of Life & synthetic biology

Chair: Claudia Bonfio

Prize ceremony

Chair: Katja Herzog, Sonsoles Martin-Santamaria, Francesco Peri

Best oral, flash or poster presentation (selected from submitted abstracts) in the field of

1) Organic chemistry interfacing Biology*

2) Innovative hit compounds and biomaterials for drug discovery and development*

3) Innovative approaches in life science*

4) Chemical tools in biology**

5) Chemical glycobiology**

6) Natural products in chemical biology**

*sponsored by the Society of Chemistry of Italy (SCI). Divisions of Organic Chemistry, Medicinal Chemistry and Chemistry in Life Sciences.

**sponsored by the Spanish Royal Society of Chemistry (RSEQ). Divisions of Chemical Biology, Carbohydrates and Natural Products.

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